Download shuttle sequentially9/13/2023 ![]() ![]() A cookie of this type is also used to store a user's decision on the use of cookies on the website. Without these cookies, which are absolutely necessary, a website could not provide certain services or functions and browsing would not be as easy and easy as it should be. These cookies are essential to enable you to navigate a website and use its full functionality. Technical cookies are technical cookies whose use does not require the user's consent. 89Zr-oxalate was obtained eluting an hydroxamate resin using 1.6ml 1M oxalic acid. Purification: Copper and Gallium were eluted from an ion exchange resin in 64Cu-chloride and 68Ga-chloride form, using 10mL 0.5M HCl and 5ml 1M HCl respectively. As with the plating processes, the dissolutions processes have been performed with separated circuits to avoid cross contaminations. The parameters for the bombardment, beam current and time, are dependent on the amount of activity needed.ĭissolution: Every irradiated target is dissolved in HCl: Nickel plating is dissolved by HCl 6M (90 ☌) Zinc plating by HCl 10M and the Yttrium foil by HCl 6M drop by drop. Irradiation: For the irradiation, the shuttle is sent to the PTS and the cooling system is switched on. Once prepared, the shuttle can be stored under room conditions. After the plating, the shuttle must be washed with water and ethanol, followed by a final dry. For this reason, 64Ni(NO 3) 2 and 68ZnCl 2 were plated with separated circuits on the platinum surface of the shuttle. Plating: Before the irradiation the target material must be plated into the shuttle. Preparation of the shuttle/irradiation (PTS).This system is composed by one irradiation unit (PTS), one dissolution/transfer unit (EDS) and one purification module (TADDEO PRF). The dissolved solution was purified to recover the enriched starting material and collect the final product: a dedicated disposable kit was used to process the radio-metal to completely avoid cross-contamination between the different productions.ĭissolution and purification steps were managed by automatic recipes.Īll phases (electroplating, delivery to cyclotron, dissolution and purification) were executed automatically by the Comecer ALCEO Solid Target. Every irradiated targets was dissolved in HCl. After irradiation, the shuttles were transferred automatically to the dissolution module. 64Ni plating, 68Zn plating and 89Y foil were bombarded with an energy range of 12-15MeV by a medical cyclotron (with a typical current from 10♚ to 35♚). Nickel and Zinc powders were electroplated onto a shuttle, while a commercial yttrium foil was inserted into a shuttle. Materials and Methodīy irradiation of a solid target via (p,n) nuclear reaction, Ga-68, Cu-64 and Zr-89 can be produced. The system uses dedicated disposable cassette and specific automatic recipes for each production avoiding any cross-contamination. The aim of this work is to demonstrate the feasibility of production of all these metal isotopes by only one automated Solid Target system. Ga-68, Cu-64 and Zr-89 are radionuclides widely used in studies of selective tumor targeting. Guidi (COMECER S.p.A., Castel Bolognese, Italy), P. Boschi (COMECER S.p.A., Castel Bolognese, Italy), G. Malinconico (COMECER S.p.A., Castel Bolognese, Italy), J. Alceo User Meeting: how to double the radioisotopes you can produce
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